The citations below show research on the modifiable lifestyle factors that impact cognitive decline.

  1. Athanasopoulos D, Karagiannis G, Tsolaki M. Recent Findings in Alzheimer Disease and Nutrition Focusing on Epigenetics. Adv Nutr. 2016 Sep 15;7(5):917-27. doi: 10.3945/an.116.012229. PMID: 27633107; PMCID: PMC5015036.
  2. Bhatti GK, Reddy AP, Reddy PH, Bhatti JS. Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer’s Disease. Front Aging Neurosci. 2020 Jan 10;11:369. doi: 10.3389/fnagi.2019.00369. PMID: 31998117; PMCID: PMC6966236.
  3. Calfio C, Gonzalez A, Singh SK, Rojo LE, Maccioni RB. The Emerging Role of Nutraceuticals and Phytochemicals in the Prevention and Treatment of Alzheimer’s Disease. J Alzheimers Dis. 2020;77(1):33-51. doi: 10.3233/JAD-200443. PMID: 32651325.
  4. Carrier M, Šimončičová E, St-Pierre MK, McKee C, Tremblay MÈ. Psychological Stress as a Risk Factor for Accelerated Cellular Aging and Cognitive Decline: The Involvement of Microglia-Neuron Crosstalk. Front Mol Neurosci. 2021 Nov 4;14:749737. doi: 10.3389/fnmol.2021.749737. PMID: 34803607; PMCID: PMC8599581.
  5. Chiu HF, Venkatakrishnan K, Wang CK. The role of nutraceuticals as a complementary therapy against various neurodegenerative diseases: A mini-review. J Tradit Complement Med. 2020 Apr 1;10(5):434-439. doi: 10.1016/j.jtcme.2020.03.008. PMID: 32953558; PMCID: PMC7484964.
  6. Killin LO, Starr JM, Shiue IJ, Russ TC. Environmental risk factors for dementia: a systematic review. BMC Geriatr. 2016 Oct 12;16(1):175. doi: 10.1186/s12877-016-0342-y. PMID: 27729011; PMCID: PMC5059894.
  7. Komleva Y, Chernykh A, Lopatina O, Gorina Y, Lokteva I, Salmina A, Gollasch M. Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration. Front Neurosci. 2021 Jan 14;14:618395. doi: 10.3389/fnins.2020.618395. PMID: 33519369; PMCID: PMC7841337.
  8. Law CK, Lam FM, Chung RC, Pang MY. Physical exercise attenuates cognitive decline and reduces behavioural problems in people with mild cognitive impairment and dementia: a systematic review. J Physiother. 2020 Jan;66(1):9-18. doi: 10.1016/j.jphys.2019.11.014. Epub 2019 Dec 13. PMID: 31843427.
  9. Maharjan R, Diaz Bustamante L, Ghattas KN, Ilyas S, Al-Refai R, Khan S. Role of Lifestyle in Neuroplasticity and Neurogenesis in an Aging Brain. Cureus. 2020 Sep 24;12(9):e10639. doi: 10.7759/cureus.10639. PMID: 33133809; PMCID: PMC7586385.
  10. Novotný M, Klimova B, Valis M. Microbiome and Cognitive Impairment: Can Any Diets Influence Learning Processes in a Positive Way? Front Aging Neurosci. 2019 Jun 28;11:170. doi: 10.3389/fnagi.2019.00170. PMID: 31316375; PMCID: PMC6609888.
  11. Phillips C. Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging. Neural Plast. 2017;2017:3589271. doi: 10.1155/2017/3589271. Epub 2017 Jun 12. PMID: 28695017; PMCID: PMC5485368.
  12. Poulose SM, Miller MG, Scott T, Shukitt-Hale B. Nutritional Factors Affecting Adult Neurogenesis and Cognitive Function. Adv Nutr. 2017 Nov 15;8(6):804-811. doi: 10.3945/an.117.016261. PMID: 29141966; PMCID: PMC5683005.
  13. Rashid MH, Zahid MF, Zain S, Kabir A, Hassan SU. The Neuroprotective Effects of Exercise on Cognitive Decline: A Preventive Approach to Alzheimer Disease. Cureus. 2020 Feb 11;12(2):e6958. doi: 10.7759/cureus.6958. PMID: 32190507; PMCID: PMC7067577.
  14. Sanborn V, Gunstad J. The Potential Mediation of the Effects of Physical Activity on Cognitive Function by the Gut Microbiome. Geriatrics (Basel). 2020 Sep 25;5(4):63. doi: 10.3390/geriatrics5040063. PMID: 32992812; PMCID: PMC7709629.
  15. Shi L, Chen SJ, Ma MY, Bao YP, Han Y, Wang YM, Shi J, Vitiello MV, Lu L. Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis. Sleep Med Rev. 2018 Aug;40:4-16. doi: 10.1016/j.smrv.2017.06.010. Epub 2017 Jul 6. PMID: 28890168.
  16. Spira AP, Gottesman RF. Sleep disturbance: an emerging opportunity for Alzheimer’s disease prevention? Int Psychogeriatr. 2017 Apr;29(4):529-531. doi: 10.1017/S1041610216002131. Epub 2016 Dec 12. PMID: 27938445; PMCID: PMC5493989.
  17. Szarc vel Szic K, Declerck K, Vidaković M, Vanden Berghe W. From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? Clin Epigenetics. 2015 Mar 25;7(1):33. doi: 10.1186/s13148-015-0068-2. PMID: 25861393; PMCID: PMC4389409.
  18. Vasefi M, Ghaboolian-Zare E, Abedelwahab H, Osu A. Environmental toxins and Alzheimer’s disease progression. Neurochem Int. 2020 Dec;141:104852. doi: 10.1016/j.neuint.2020.104852. Epub 2020 Sep 30. PMID: 33010393.
  19. Vinuesa A, Pomilio C, Gregosa A, Bentivegna M, Presa J, Bellotto M, Saravia F, Beauquis J. Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer’s Disease. Front Neurosci. 2021 Apr 23;15:653651. doi: 10.3389/fnins.2021.653651. PMID: 33967682; PMCID: PMC8102834.
  20. Wajman JR, Mansur LL, Yassuda MS. Lifestyle Patterns as a Modifiable Risk Factor for Late-life Cognitive Decline: A Narrative Review Regarding Dementia Prevention. Curr Aging Sci. 2018;11(2):90-99. doi: 10.2174/1874609811666181003160225. PMID: 30280679.
  21. Zhu S, Jiang Y, Xu K, Cui M, Ye W, Zhao G, Jin L, Chen X. The progress of gut microbiome research related to brain disorders. J Neuroinflammation. 2020 Jan 17;17(1):25. doi: 10.1186/s12974-020-1705-z. PMID: 31952509; PMCID: PMC6969442.