References for Functional Health Treatments for Depression

  1. Sekhon S, Gupta V. Mood Disorder. [Updated 2021 Nov 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan
  4. Villarroel MA, Terlizzi EP. Symptoms of depression among adults: United States, 2019. NCHS Data Brief, no 379. Hyattsville, MD: National Center for Health Statistics. 2020.Albert PR, Benkelfat C, Descarries L. The neurobiology of depression–revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 5;367(1601):2378-81. doi: 10.1098/rstb.2012.0190. PMID: 22826338; PMCID: PMC3405681.
  5. Alemi F, Min H, Yousefi M, Becker LK, Hane CA, Nori VS, Wojtusiak J. Effectiveness of common antidepressants: a post market release study. EClinicalMedicine. 2021 Oct 25;41:101171. doi: 10.1016/j.eclinm.2021.101171. PMID: 34877511; PMCID: PMC8633963.
  6. Yuan Z, Chen Z, Xue M, Zhang J, Leng L. Application of antidepressants in depression: A systematic review and meta-analysis. J Clin Neurosci. 2020 Oct;80:169-181. doi: 10.1016/j.jocn.2020.08.013. Epub 2020 Aug 19. PMID: 33099342.
  7. Hedaya, Robert. “Functional Medicine for Depressive Disorder: Advances in the Treatment Paradigm (Part 1).” Cleveland Clinic Center for Functional Medicine Rounds, Dec. 2017,
  8. Yang T, Nie Z, Shu H, Kuang Y, Chen X, Cheng J, Yu S, Liu H. The Role of BDNF on Neural Plasticity in Depression. Front Cell Neurosci. 2020 Apr 15;14:82. doi: 10.3389/fncel.2020.00082. PMID: 32351365; PMCID: PMC7174655.
  9. Caviedes A, Lafourcade C, Soto C, Wyneken U. BDNF/NF-κB Signaling in the Neurobiology of Depression. Curr Pharm Des. 2017;23(21):3154-3163. doi: 10.2174/1381612823666170111141915. PMID: 28078988.
  10. Jin Y, Sun LH, Yang W, Cui RJ, Xu SB. The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders. Front Neurol. 2019 Jun 4;10:515. doi: 10.3389/fneur.2019.00515. PMID: 31231295; PMCID: PMC6559010.
  11. Doyle, C., Swain, W., Swain Ewald, H., & Ewald, P. (2019). Inflammation, infection and depression: An evolutionary perspective. Evolutionary Human Sciences, 1, E14.
  12. Firth J, Veronese N, Cotter J, Shivappa N, Hebert JR, Ee C, Smith L, Stubbs B, Jackson SE, Sarris J. What Is the Role of Dietary Inflammation in Severe Mental Illness? A Review of Observational and Experimental Findings. Front Psychiatry. 2019 May 15;10:350. doi: 10.3389/fpsyt.2019.00350. PMID: 31156486; PMCID: PMC6529779.
  13. Webb M, Davies M, Ashra N, Bodicoat D, Brady E, Webb D, Moulton C, Ismail K, Khunti K. The association between depressive symptoms and insulin resistance, inflammation and adiposity in men and women. PLoS One. 2017 Nov 30;12(11):e0187448. doi: 10.1371/journal.pone.0187448. PMID: 29190710; PMCID: PMC5708702.
  14. Mariani N, Everson J, Pariante CM, Borsini A. Modulation of microglial activation by antidepressants. J Psychopharmacol. 2022 Feb;36(2):131-150. doi: 10.1177/02698811211069110. Epub 2022 Jan 29. PMID: 35098788; PMCID: PMC8847767.
  15. Nieto-Quero A, Chaves-Peña P, Santín LJ, Pérez-Martín M, Pedraza C. Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models. Neurobiol Stress. 2021 Jun 18;15:100356. doi: 10.1016/j.ynstr.2021.100356. PMID: 34355047; PMCID: PMC8319800.
  16. Zhang L, Zhang J, You Z. Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder. Front Cell Neurosci. 2018 Oct 16;12:306. doi: 10.3389/fncel.2018.00306. PMID: 30459555; PMCID: PMC6232769.
  17. Frick LR, Williams K, Pittenger C. Microglial dysregulation in psychiatric disease. Clin Dev Immunol. 2013;2013:608654. doi: 10.1155/2013/608654. Epub 2013 Apr 18. PMID: 23690824; PMCID: PMC3652125.
  18. Deng SL, Chen JG, Wang F. Microglia: A Central Player in Depression. Curr Med Sci. 2020 Jun;40(3):391-400. doi: 10.1007/s11596-020-2193-1. Epub 2020 Jul 17. PMID: 32681244.
  19. Yirmiya R, Rimmerman N, Reshef R. Depression as a microglial disease. Trends Neurosci. 2015 Oct;38(10):637-658. doi: 10.1016/j.tins.2015.08.001. PMID: 26442697.
  20. Wohleb ES. Neuron-Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”. Front Immunol. 2016 Nov 29;7:544. doi: 10.3389/fimmu.2016.00544. PMID: 27965671; PMCID: PMC5126117.
  21. Turkin A, Tuchina O, Klempin F. Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. Front Cell Dev Biol. 2021 May 24;9:665739. doi: 10.3389/fcell.2021.665739. PMID: 34109176; PMCID: PMC8182052.
  22. Miller AH. Beyond depression: the expanding role of inflammation in psychiatric disorders. World Psychiatry. 2020 Feb;19(1):108-109. doi: 10.1002/wps.20723. PMID: 31922681; PMCID: PMC6953590.
  23. Miller AH, Raison CL. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol. 2016 Jan;16(1):22-34. doi: 10.1038/nri.2015.5. PMID: 26711676; PMCID: PMC5542678.
  24. Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008 Jan;9(1):46-56. doi: 10.1038/nrn2297. PMID: 18073775; PMCID: PMC2919277.
  25. Abdoli A, Taghipour A, Pirestani M, Mofazzal Jahromi MA, Roustazadeh A, Mir H, Ardakani HM, Kenarkoohi A, Falahi S, Karimi M. Infections, inflammation, and risk of neuropsychiatric disorders: the neglected role of “co-infection”. Heliyon. 2020 Dec 8;6(12):e05645. doi: 10.1016/j.heliyon.2020.e05645. PMID: 33319101; PMCID: PMC7725732.
  26. Wachowska K, Gałecki P. Inflammation and Cognition in Depression: A Narrative Review. J Clin Med. 2021 Dec 14;10(24):5859. doi: 10.3390/jcm10245859. PMID: 34945157; PMCID: PMC8706670.
  27. Liu YZ, Wang YX, Jiang CL. Inflammation: The Common Pathway of Stress-Related Diseases. Front Hum Neurosci. 2017 Jun 20;11:316. doi: 10.3389/fnhum.2017.00316. PMID: 28676747; PMCID: PMC5476783.
  28. Hersey M, Samaranayake S, Berger SN, Tavakoli N, Mena S, Nijhout HF, Reed MC, Best J, Blakely RD, Reagan LP, Hashemi P. Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin. J Neurosci. 2021 Jul 28;41(30):6564-6577. doi: 10.1523/JNEUROSCI.2618-20.2021. Epub 2021 Jun 3. PMID: 34083254; PMCID: PMC8318079.
  29. Christmas DM, Potokar J, Davies SJ. A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase. Neuropsychiatr Dis Treat. 2011;7:431-9. doi: 10.2147/NDT.S17573. Epub 2011 Jul 13. PMID: 21792309; PMCID: PMC3140295.
  30. Dantzer R, O’Connor JC, Lawson MA, Kelley KW. Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology. 2011 Apr;36(3):426-36. doi: 10.1016/j.psyneuen.2010.09.012. Epub 2010 Oct 30. PMID: 21041030; PMCID: PMC3053088.
  31. Beurel E, Toups M, Nemeroff CB. The Bidirectional Relationship of Depression and Inflammation: Double Trouble. Neuron. 2020 Jul 22;107(2):234-256. doi: 10.1016/j.neuron.2020.06.002. Epub 2020 Jun 17. PMID: 32553197; PMCID: PMC7381373.
  32. Frank P, Jokela M, Batty GD, Cadar D, Steptoe A, Kivimäki M. Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies. Am J Psychiatry. 2021 Dec;178(12):1107-1118. doi: 10.1176/appi.ajp.2021.20121776. Epub 2021 Oct 14. PMID: 34645276.
  33. Milaneschi Y, Kappelmann N, Ye Z, Lamers F, Moser S, Jones PB, Burgess S, Penninx BWJH, Khandaker GM. Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts. Mol Psychiatry. 2021 Jun 16. doi: 10.1038/s41380-021-01188-w. Epub ahead of print. Erratum in: Mol Psychiatry. 2021 Nov 16;: PMID: 34135474.
  34. Berk M, Williams LJ, Jacka FN, O’Neil A, Pasco JA, Moylan S, Allen NB, Stuart AL, Hayley AC, Byrne ML, Maes M. So depression is an inflammatory disease, but where does the inflammation come from? BMC Med. 2013 Sep 12;11:200. doi: 10.1186/1741-7015-11-200. PMID: 24228900; PMCID: PMC3846682.
  35. Morrens M, Coppens V, Walther S. Do Immune Dysregulations and Oxidative Damage Drive Mood and Psychotic Disorders? Neuropsychobiology. 2020;79(4-5):251-254. doi: 10.1159/000496622. Epub 2019 Apr 16. PMID: 30991415.
  36. Bauer ME, Teixeira AL. Neuroinflammation in Mood Disorders: Role of Regulatory Immune Cells. Neuroimmunomodulation. 2021;28(3):99-107. doi: 10.1159/000515594. Epub 2021 May 5. PMID: 33951643.
  37. Colpo GD, Leboyer M, Dantzer R, Trivedi MH, Teixeira AL. Immune-based strategies for mood disorders: facts and challenges. Expert Rev Neurother. 2018 Feb;18(2):139-152. doi: 10.1080/14737175.2018.1407242. Epub 2017 Nov 27. PMID: 29179585; PMCID: PMC5819337.
  38. Mocking RJT, Naviaux JC, Li K, Wang L, Monk JM, Bright AT, Figueroa CA, Schene AH, Ruhé HG, Assies J, Naviaux RK. Metabolic features of recurrent major depressive disorder in remission, and the risk of future recurrence. Transl Psychiatry. 2021 Jan 11;11(1):37. doi: 10.1038/s41398-020-01182-w. Erratum in: Transl Psychiatry. 2021 Feb 8;11(1):115. PMID: 33431800; PMCID: PMC7801396.
  39. Jeremiah OJ, Cousins G, Boland F, Kirby BP, Ryan BK. Evaluation of the effect of insulin sensitivity-enhancing lifestyle- and dietary-related adjuncts on antidepressant treatment response: A systematic review and meta-analysis. Heliyon. 2020 Sep 15;6(9):e04845. doi: 10.1016/j.heliyon.2020.e04845. PMID: 32995594; PMCID: PMC7502352.
  40. Geraets AFJ, Köhler S, Muzambi R, Schalkwijk CG, Oenema A, Eussen SJPM, Dagnelie PC, Stehouwer CDA, Schaper NC, Henry RMA, van der Kallen CJH, Wesselius A, Koster A, Verhey FRJ, Schram MT. The association of hyperglycaemia and insulin resistance with incident depressive symptoms over 4 years of follow-up: The Maastricht Study. Diabetologia. 2020 Nov;63(11):2315-2328. doi: 10.1007/s00125-020-05247-9. Epub 2020 Aug 5. PMID: 32757152; PMCID: PMC7527373.
  41. Zou XH, Sun LH, Yang W, Li BJ, Cui RJ. Potential role of insulin on the pathogenesis of depression. Cell Prolif. 2020 May;53(5):e12806. doi: 10.1111/cpr.12806. Epub 2020 Apr 13. PMID: 32281722; PMCID: PMC7260070.
  42. Hamer JA, Testani D, Mansur RB, Lee Y, Subramaniapillai M, McIntyre RS. Brain insulin resistance: A treatment target for cognitive impairment and anhedonia in depression. Exp Neurol. 2019 May;315:1-8. doi: 10.1016/j.expneurol.2019.01.016. Epub 2019 Jan 26. PMID: 30695707.
  43. Lyra E Silva NM, Lam MP, Soares CN, Munoz DP, Milev R, De Felice FG. Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes. Front Psychiatry. 2019 Feb 14;10:57. doi: 10.3389/fpsyt.2019.00057. PMID: 30837902; PMCID: PMC6382695.
  44. Calkin CV. Insulin resistance takes center stage: a new paradigm in the progression of bipolar disorder. Ann Med. 2019 Aug-Sep;51(5-6):281-293. doi: 10.1080/07853890.2019.1659511. Epub 2019 Aug 27. PMID: 31453713; PMCID: PMC7877881.
  45. Calkin C, McClelland C, Cairns K, Kamintsky L, Friedman A. Insulin Resistance and Blood-Brain Barrier Dysfunction Underlie Neuroprogression in Bipolar Disorder. Front Psychiatry. 2021 May 25;12:636174. doi: 10.3389/fpsyt.2021.636174. PMID: 34113269; PMCID: PMC8185298.
  46. Watson KT, Simard JF, Henderson VW, Nutkiewicz L, Lamers F, Nasca C, Rasgon N, Penninx BWJH. Incident Major Depressive Disorder Predicted by Three Measures of Insulin Resistance: A Dutch Cohort Study. Am J Psychiatry. 2021 Oct 1;178(10):914-920. doi: 10.1176/appi.ajp.2021.20101479. Epub 2021 Sep 23. PMID: 34551583.
  47. Borsini, A., Nicolaou, A., Camacho-Muñoz, D. et al. Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis. Mol Psychiatry 26, 6773–6788 (2021).
  48. Pannu A, Sharma PC, Thakur VK, Goyal RK. Emerging Role of Flavonoids as the Treatment of Depression. Biomolecules. 2021 Dec 3;11(12):1825. doi: 10.3390/biom11121825. PMID: 34944471; PMCID: PMC8698856.
  49. Tolkien K, Bradburn S, Murgatroyd C. An anti-inflammatory diet as a potential intervention for depressive disorders: A systematic review and meta-analysis. Clin Nutr. 2019 Oct;38(5):2045-2052. doi: 10.1016/j.clnu.2018.11.007. Epub 2018 Nov 20. PMID: 30502975.
  50. Ljungberg T, Bondza E, Lethin C. Evidence of the Importance of Dietary Habits Regarding Depressive Symptoms and Depression. Int J Environ Res Public Health. 2020 Mar 2;17(5):1616. doi: 10.3390/ijerph17051616. PMID: 32131552; PMCID: PMC7084175.
  51. Firth J, Gangwisch JE, Borisini A, Wootton RE, Mayer EA. Food and mood: how do diet and nutrition affect mental wellbeing? BMJ. 2020 Jun 29;369:m2382. doi: 10.1136/bmj.m2382. Erratum in: BMJ. 2020 Nov 9;371:m4269. PMID: 32601102; PMCID: PMC7322666.
  52. Muscaritoli M. The Impact of Nutrients on Mental Health and Well-Being: Insights From the Literature. Front Nutr. 2021 Mar 8;8:656290. doi: 10.3389/fnut.2021.656290. PMID: 33763446; PMCID: PMC7982519.
  53. Sarris J, Murphy J, Mischoulon D, Papakostas GI, Fava M, Berk M, Ng CH. Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. Am J Psychiatry. 2016 Jun 1;173(6):575-87. doi: 10.1176/appi.ajp.2016.15091228. Epub 2016 Apr 26. PMID: 27113121.
  54. Spedding S. Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients. 2014 Apr 11;6(4):1501-18. doi: 10.3390/nu6041501. PMID: 24732019; PMCID: PMC4011048.
  55. Siegmann EM, Müller HHO, Luecke C, Philipsen A, Kornhuber J, Grömer TW. Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2018 Jun 1;75(6):577-584. doi: 10.1001/jamapsychiatry.2018.0190. Erratum in: JAMA Psychiatry. 2019 Jun 19;: PMID: 29800939; PMCID: PMC6137529.
  56. Benros ME, Waltoft BL, Nordentoft M, Ostergaard SD, Eaton WW, Krogh J, Mortensen PB. Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study. JAMA Psychiatry. 2013 Aug;70(8):812-20. doi: 10.1001/jamapsychiatry.2013.1111. PMID: 23760347.
  57. Braithwaite I, Zhang S, Kirkbride JB, Osborn DPJ, Hayes JF. Air Pollution (Particulate Matter) Exposure and Associations with Depression, Anxiety, Bipolar, Psychosis and Suicide Risk: A Systematic Review and Meta-Analysis. Environ Health Perspect. 2019 Dec;127(12):126002. doi: 10.1289/EHP4595. Epub 2019 Dec 18. PMID: 31850801; PMCID: PMC6957283.
  58. Ali NA, Khoja A. Growing Evidence for the Impact of Air Pollution on Depression. Ochsner J. 2019 Spring;19(1):4. doi: 10.31486/toj.19.0011. PMID: 30983893; PMCID: PMC6447209.
  59. Kim KW, Sreeja SR, Kwon M, Yu YL, Kim MK. Association of Blood Mercury Level with the Risk of Depression According to Fish Intake Level in the General Korean Population: Findings from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008-2013. Nutrients. 2020 Jan 9;12(1):189. doi: 10.3390/nu12010189. PMID: 31936641; PMCID: PMC7019861.
  60. Ayuso-Álvarez A, Simón L, Nuñez O, Rodríguez-Blázquez C, Martín-Méndez I, Bel-Lán A, López-Abente G, Merlo J, Fernandez-Navarro P, Galán I. Association between heavy metals and metalloids in topsoil and mental health in the adult population of Spain. Environ Res. 2019 Dec;179(Pt A):108784. doi: 10.1016/j.envres.2019.108784. Epub 2019 Sep 28. PMID: 31606614.
  61. Bauer M, Goetz T, Glenn T, Whybrow PC. The thyroid-brain interaction in thyroid disorders and mood disorders. J Neuroendocrinol. 2008 Oct;20(10):1101-14. doi: 10.1111/j.1365-2826.2008.01774.x. Epub 2008 Jul 30. PMID: 18673409.
  62. Pilhatsch M, Marxen M, Winter C, Smolka MN, Bauer M. Hypothyroidism and mood disorders: integrating novel insights from brain imaging techniques. Thyroid Res. 2011 Aug 3;4 Suppl 1(Suppl 1):S3. doi: 10.1186/1756-6614-4-S1-S3. PMID: 21835050; PMCID: PMC3155109.
  63. Chávez-Castillo M, Núñez V, Nava M, Ortega Á, Rojas M, Bermúdez V, Rojas-Quintero J. Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines. Adv Pharmacol Sci. 2019 Jan 3;2019:7943481. doi: 10.1155/2019/7943481. PMID: 30719038; PMCID: PMC6335777.
  64. van den Bosch M, Meyer-Lindenberg A. Environmental Exposures and Depression: Biological Mechanisms and Epidemiological Evidence. Annu Rev Public Health. 2019 Apr 1;40:239-259. doi: 10.1146/annurev-publhealth-040218-044106. Epub 2019 Jan 11. PMID: 30633709.
  65. Hollander JA, Cory-Slechta DA, Jacka FN, Szabo ST, Guilarte TR, Bilbo SD, Mattingly CJ, Moy SS, Haroon E, Hornig M, Levin ED, Pletnikov MV, Zehr JL, McAllister KA, Dzierlenga AL, Garton AE, Lawler CP, Ladd-Acosta C. Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease. Neuropsychopharmacology. 2020 Jun;45(7):1086-1096. doi: 10.1038/s41386-020-0648-5. Epub 2020 Feb 28. PMID: 32109936; PMCID: PMC7234981.
  66. Kobayashi N, Oka N, Takahashi M, Shimada K, Ishii A, Tatebayashi Y, Shigeta M, Yanagisawa H, Kondo K. Human Herpesvirus 6B Greatly Increases Risk of Depression by Activating Hypothalamic-Pituitary -Adrenal Axis during Latent Phase of Infection. iScience. 2020 Jun 26;23(6):101187. doi: 10.1016/j.isci.2020.101187. Epub 2020 May 21. PMID: 32534440; PMCID: PMC7298549.
  67. Prusty BK, Gulve N, Govind S, Krueger GRF, Feichtinger J, Larcombe L, Aspinall R, Ablashi DV, Toro CT. Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders. Front Microbiol. 2018 Aug 21;9:1955. doi: 10.3389/fmicb.2018.01955. PMID: 30186267; PMCID: PMC6110891.
  68. Liao YT, Hsieh MH, Yang YH, Wang YC, Tsai CS, Chen VC, Gossop M. Association between depression and enterovirus infection: A nationwide population-based cohort study. Medicine (Baltimore). 2017 Feb;96(5):e5983. doi: 10.1097/MD.0000000000005983. PMID: 28151890; PMCID: PMC5293453.
  69. Doney E, Cadoret A, Dion-Albert L, Lebel M, Menard C. Inflammation-driven brain and gut barrier dysfunction in stress and mood disorders. Eur J Neurosci. 2021 Apr 20. doi: 10.1111/ejn.15239. Epub ahead of print. PMID: 33876886.
  70. Madison AA, Andridge R, Padin AC, Wilson S, Bailey MT, Alfano CM, Povoski SP, Lipari AM, Agnese DM, Carson WE, Malarkey WB, Kiecolt-Glaser JK. Endotoxemia coupled with heightened inflammation predicts future depressive symptoms. Psychoneuroendocrinology. 2020 Dec;122:104864. doi: 10.1016/j.psyneuen.2020.104864. Epub 2020 Oct 8. PMID: 33166799; PMCID: PMC7721058.
  71. Lasselin J, Lekander M, Benson S, Schedlowski M, Engler H. Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression. Mol Psychiatry. 2021 Aug;26(8):3672-3683. doi: 10.1038/s41380-020-00869-2. Epub 2020 Sep 1. PMID: 32873895; PMCID: PMC8550942.
  72. Kelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G, Hyland NP. Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci. 2015 Oct 14;9:392. doi: 10.3389/fncel.2015.00392. PMID: 26528128; PMCID: PMC4604320.
  73. Kunugi H. Gut Microbiota and Pathophysiology of Depressive Disorder. Ann Nutr Metab. 2021;77 Suppl 2:11-20. doi: 10.1159/000518274. Epub 2021 Jul 28. PMID: 34350881.
  74. Liu L, Zhu G. Gut-Brain Axis and Mood Disorder. Front Psychiatry. 2018 May 29;9:223. doi: 10.3389/fpsyt.2018.00223. PMID: 29896129; PMCID: PMC5987167.
  75. Du Y, Gao XR, Peng L, Ge JF. Crosstalk between the microbiota-gut-brain axis and depression. Heliyon. 2020 Jun 3;6(6):e04097. doi: 10.1016/j.heliyon.2020.e04097. PMID: 32529075; PMCID: PMC7276434.
  76. Ortega MA, Alvarez-Mon MA, García-Montero C, Fraile-Martinez O, Guijarro LG, Lahera G, Monserrat J, Valls P, Mora F, Rodríguez-Jiménez R, Quintero J, Álvarez-Mon M. Gut Microbiota Metabolites in Major Depressive Disorder-Deep Insights into Their Pathophysiological Role and Potential Translational Applications. Metabolites. 2022 Jan 8;12(1):50. doi: 10.3390/metabo12010050. PMID: 35050172; PMCID: PMC8778125.
  77. Caspani G, Kennedy S, Foster JA, Swann J. Gut microbial metabolites in depression: understanding the biochemical mechanisms. Microb Cell. 2019 Sep 27;6(10):454-481. doi: 10.15698/mic2019.10.693. PMID: 31646148; PMCID: PMC6780009.
  78. Suda K, Matsuda K. How Microbes Affect Depression: Underlying Mechanisms via the Gut-Brain Axis and the Modulating Role of Probiotics. Int J Mol Sci. 2022 Jan 21;23(3):1172. doi: 10.3390/ijms23031172. PMID: 35163104; PMCID: PMC8835211.
  79. Audet MC. Beyond the neuro-immune interplay in depression: Could gut microbes be the missing link? Brain Behav Immun Health. 2021 Aug 4;16:100308. doi: 10.1016/j.bbih.2021.100308. PMID: 34589800; PMCID: PMC8474680.
  80. Martínez M, Postolache TT, García-Bueno B, Leza JC, Figuero E, Lowry CA, Malan-Müller S. The Role of the Oral Microbiota Related to Periodontal Diseases in Anxiety, Mood and Trauma- and Stress-Related Disorders. Front Psychiatry. 2022 Jan 27;12:814177. doi: 10.3389/fpsyt.2021.814177. PMID: 35153869; PMCID: PMC8833739.
  81. Li NP, van Vugt M, Colarelli SM. The Evolutionary Mismatch Hypothesis: Implications for Psychological Science. Communication Research. 2018;27(1):775-792. Montgomery, J. Evolutionary Mismatch, Emotional Homeostasis, and “Emotional Addiction”: A Unifying Model of Psychological Dysfunction. Evolutionary Psychological Science 4, 428–442 (2018).
  82. Rantala MJ, Luoto S, Borráz-León JI, Krams I. Bipolar disorder: An evolutionary psychoneuroimmunological approach. Neurosci Biobehav Rev. 2021 Mar;122:28-37. doi: 10.1016/j.neubiorev.2020.12.031. Epub 2021 Jan 6. Erratum in: Neurosci Biobehav Rev. 2021 Jul;126:528. PMID: 33421542.
  83. Santarelli S, Lesuis SL, Wang XD, Wagner KV, Hartmann J, Labermaier C, Scharf SH, Müller MB, Holsboer F, Schmidt MV. Evidence supporting the match/mismatch hypothesis of psychiatric disorders. Eur Neuropsychopharmacol. 2014 Jun;24(6):907-18. doi: 10.1016/j.euroneuro.2014.02.002. Epub 2014 Feb 15. PMID: 24589292.
  84. Shadrina M, Bondarenko EA, Slominsky PA. Genetics Factors in Major Depression Disease. Front Psychiatry. 2018 Jul 23;9:334. doi: 10.3389/fpsyt.2018.00334. PMID: 30083112; PMCID: PMC6065213.
  85. Lopizzo N, Bocchio Chiavetto L, Cattane N, Plazzotta G, Tarazi FI, Pariante CM, Riva MA, Cattaneo A. Gene-environment interaction in major depression: focus on experience-dependent biological systems. Front Psychiatry. 2015 May 8;6:68. doi: 10.3389/fpsyt.2015.00068. PMID: 26005424; PMCID: PMC4424810.
  86. Alam R, Abdolmaleky HM, Zhou JR. Microbiome, inflammation, epigenetic alterations, and mental diseases. Am J Med Genet B Neuropsychiatr Genet. 2017 Sep;174(6):651-660. doi: 10.1002/ajmg.b.32567. Epub 2017 Jul 10. PMID: 28691768.
  87. Nestler EJ, Peña CJ, Kundakovic M, Mitchell A, Akbarian S. Epigenetic Basis of Mental Illness. Neuroscientist. 2016 Oct;22(5):447-63. doi: 10.1177/1073858415608147. Epub 2015 Oct 8. PMID: 26450593; PMCID: PMC4826318.
  88. Jehan S, Auguste E, Pandi-Perumal SR, Kalinowski J, Myers AK, Zizi F, Rajanna MG, Jean-Louis G, McFarlane SI. Depression, Obstructive Sleep Apnea and Psychosocial Health. Sleep Med Disord. 2017;1(3):00012. Epub 2017 Oct 27. PMID: 29517078; PMCID: PMC5836734.
  89. Lin IM, Fan SY, Yen CF, Yeh YC, Tang TC, Huang MF, Liu TL, Wang PW, Lin HC, Tsai HY, Tsai YC. Heart Rate Variability Biofeedback Increased Autonomic Activation and Improved Symptoms of Depression and Insomnia among Patients with Major Depression Disorder. Clin Psychopharmacol Neurosci. 2019 May 31;17(2):222-232. doi: 10.9758/cpn.2019.17.2.222. Erratum in: Clin Psychopharmacol Neurosci. 2019 Aug 31;17(3):458. PMID: 30905122; PMCID: PMC6478078.
  90. Pizzoli SFM, Marzorati C, Gatti D, Monzani D, Mazzocco K, Pravettoni G. A meta-analysis on heart rate variability biofeedback and depressive symptoms. Sci Rep. 2021 Mar 23;11(1):6650. doi: 10.1038/s41598-021-86149-7. PMID: 33758260; PMCID: PMC7988005.
  91. Pizzoli SFM, Marzorati C, Gatti D, Monzani D, Mazzocco K, Pravettoni G. A meta-analysis on heart rate variability biofeedback and depressive symptoms. Sci Rep. 2021 Mar 23;11(1):6650. doi: 10.1038/s41598-021-86149-7. PMID: 33758260; PMCID: PMC7988005.
  92. Picard M, McEwen BS. Psychological Stress and Mitochondria: A Systematic Review. Psychosom Med. 2018 Feb/Mar;80(2):141-153. doi: 10.1097/PSY.0000000000000545. PMID: 29389736; PMCID: PMC5901654.
  93. Giménez-Palomo A, Dodd S, Anmella G, Carvalho AF, Scaini G, Quevedo J, Pacchiarotti I, Vieta E, Berk M. The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment. Front Psychiatry. 2021 Jul 6;12:546801. doi: 10.3389/fpsyt.2021.546801. PMID: 34295268; PMCID: PMC8291901.
  94. Allen J, Romay-Tallon R, Brymer KJ, Caruncho HJ, Kalynchuk LE. Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression. Front Neurosci. 2018 Jun 6;12:386. doi: 10.3389/fnins.2018.00386. PMID: 29928190; PMCID: PMC5997778.
  95. Jorge RE, Arciniegas DB. Mood disorders after TBI. Psychiatr Clin North Am. 2014 Mar;37(1):13-29. doi: 10.1016/j.psc.2013.11.005. Epub 2014 Jan 14. PMID: 24529421; PMCID: PMC3985339.
  96. Robert S. Traumatic brain injury and mood disorders. Ment Health Clin. 2020 Nov 5;10(6):335-345. doi: 10.9740/mhc.2020.11.335. PMID: 33224691; PMCID: PMC7653730.
  97. Walker WH 2nd, Walton JC, DeVries AC, Nelson RJ. Circadian rhythm disruption and mental health. Transl Psychiatry. 2020 Jan 23;10(1):28. doi: 10.1038/s41398-020-0694-0. PMID: 32066704; PMCID: PMC7026420.
  98. Huang Y, Li L, Gan Y, Wang C, Jiang H, Cao S, Lu Z. Sedentary behaviors and risk of depression: a meta-analysis of prospective studies. Transl Psychiatry. 2020 Jan 22;10(1):26. doi: 10.1038/s41398-020-0715-z. PMID: 32066686; PMCID: PMC7026102.
  99. Schuch FB, Stubbs B. The Role of Exercise in Preventing and Treating Depression. Curr Sports Med Rep. 2019 Aug;18(8):299-304. doi: 10.1249/JSR.0000000000000620. PMID: 31389872.